The effect on adipose tissue blood flow of isoenergetic meals containing different amounts and types of fat.

Journal article

OBJECTIVE: To investigate the factors regulating the increase in adipose tissue blood flow following meals. DESIGN: Eight subjects were fed three isoenergetic meals; two high-fat meals rich in either saturated or polyunsaturated fatty acids and one low-fat, high-carbohydrate meal. MEASUREMENTS: Blood samples were taken and adipose tissue blood flow was measured before and for 6 h after the meal. Plasma glucose, insulin, non-esterified fatty acid, total and chylomicron-triacylglycerol and catecholamine concentrations were measured. RESULTS: Adipose tissue blood flow rose to a peak after all three meals (P<0.05 for each). The three meals stimulated adipose tissue blood flow at similar times. There was a marked and statistically significant similarity in the time course of changes in blood flow and insulin concentrations. In contrast, noradrenaline concentrations peaked later than adipose tissue blood flow (P=0.014). CONCLUSION: Adipose tissue blood flow may be 'carbohydrate-stimulated' rather than 'fat-stimulated', with insulin having a vasodilatory role in adipose tissue as in skeletal muscle.

Authors: Summers, L; Callow, J; Samra, J; Macdonald, I; Matthews, DR

• Publication status: Published
• Journal: International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity
• Volume: 25
• Issue: 9
• Pages: 1294-1299
• Publication date: 2001-09-01
• DOI: 10.1038/sj.ijo.0801675
• ISSN: 0307-0565
• Language: English
• Keywords: Fatty Acids, Nonesterified; Triglycerides; Blood Glucose; Dietary Fats; Time Factors; Postprandial Period; Chylomicrons; Male; Insulin; Catecholamines; Humans; Dietary Carbohydrates; Adult; Middle Aged; Area Under Curve; Adipose Tissue