Journal article icon

Journal article

Use of complete eluted peptide sequence data from HLA-DR and -DQ molecules to predict T cell epitopes, and the influence of the nonbinding terminal regions of ligands in epitope selection.

Abstract:

In diseases with a strong association with an HLA haplotype, identification of relevant T cell epitopes may allow alteration of the pathologic process. In this report we use a reverse immunogenetic approach to predict possible HLA class II-restricted T cell epitopes by using complete pool sequencing data. Data from HLA-DR2(B1*1501), -DR3(B1*0301), -DQ2(A1*0501, B1*0201), and -DQ8(A1*0301, B1*0302) alleles were used by a computer program that searches a candidate protein to predict ligands wit...

Expand abstract
Publication status:
Published

Actions


Authors


Godkin, AJ More by this author
Davenport, MP More by this author
Jewell, DP More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute, Biomedical Research Centre
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
161
Issue:
2
Pages:
850-858
Publication date:
1998-07-05
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:19a68657-13aa-43b0-9653-4d7910f486e3
Source identifiers:
36206
Local pid:
pubs:36206

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP