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Immunological effect of administration of sequential doses of Haemophilus influenzae type b and pneumococcal conjugate vaccines in the same versus alternating limbs in the routine infant immunisation schedule: an open-label randomised controlled trial.

Abstract:

BACKGROUND: The use of different limbs for the administration of sequential doses of an intradermal rabies vaccine was shown to result in reduced vaccine immunogenicity. We aimed to assess whether this phenomenon also occurs with routine infant vaccines. METHODS: In this open-label, randomised, controlled study, eligible healthy infants 6-12 weeks of age recruited through five clinical trials units (four in the UK and one in Malta) were randomly assigned in a 1:1 ratio to two vaccination grou...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences
Role:
Author
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Publisher:
Lancet Publishing Group
Journal:
The Lancet. Infectious diseases
Volume:
15
Issue:
2
Pages:
172-180
Publication date:
2015-01-05
DOI:
EISSN:
1474-4457
ISSN:
1473-3099
URN:
uuid:19a670aa-53fd-42c0-b6f4-c1bd71e2380a
Source identifiers:
503589
Local pid:
pubs:503589
Language:
English

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