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Immunological effect of administration of sequential doses of Haemophilus influenzae type b and pneumococcal conjugate vaccines in the same versus alternating limbs in the routine infant immunisation schedule: an open-label randomised controlled trial.

Abstract:

BACKGROUND: The use of different limbs for the administration of sequential doses of an intradermal rabies vaccine was shown to result in reduced vaccine immunogenicity. We aimed to assess whether this phenomenon also occurs with routine infant vaccines. METHODS: In this open-label, randomised, controlled study, eligible healthy infants 6-12 weeks of age recruited through five clinical trials units (four in the UK and one in Malta) were randomly assigned in a 1:1 ratio to two vaccination grou...

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Publication status:
Published

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Publisher copy:
10.1016/s1473-3099(14)71057-6

Authors

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Institution:
University of Oxford
Division:
MSD
Department:
Primary Care Health Sciences
Role:
Author


Publisher:
Lancet
Journal:
Lancet. Infectious diseases More from this journal
Volume:
15
Issue:
2
Pages:
172-180
Publication date:
2015-01-01
DOI:
EISSN:
1474-4457
ISSN:
1473-3099


Language:
English
Pubs id:
pubs:503589
UUID:
uuid:19a670aa-53fd-42c0-b6f4-c1bd71e2380a
Local pid:
pubs:503589
Source identifiers:
503589
Deposit date:
2015-01-27
ARK identifier:

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