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Development of NIRS method for quality control of drug combination artesunate-azithromycin for the treatment of severe malaria.

Abstract:

Near infrared spectroscopy (NIRS) methods were developed for the determination of analytical content of an antimalarial-antibiotic (artesunate and azithromycin) co-formulation in hard gelatin capsule (HGC). The NIRS consists of pre-processing treatment of spectra (raw spectra and first-derivation of two spectral zones), a unique principal component analysis model to ensure the specificity and then two partial least-squares regression models for the determination content of each active pharmac...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.jpba.2012.04.009

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Wellcome Trust More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Journal of Pharmaceutical and Biomedical Analysis Journal website
Volume:
67-68
Pages:
10-15
Publication date:
2012-01-01
DOI:
EISSN:
1873-264X
ISSN:
0731-7085
URN:
uuid:19a408b3-081e-4379-b067-0bf291603fb1
Source identifiers:
333960
Local pid:
pubs:333960

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