Journal article
Somatosensory and psychological phenotypes associated with neuropathic pain in entrapment neuropathy
- Abstract:
- It currently remains unclear why some patients with entrapment neuropathies develop neuropathic pain (neuP), whereas others have non-neuP, presumably of nociceptive character. Studying patients with carpal tunnel syndrome (CTS), this cross-sectional cohort study investigated changes in somatosensory structure and function as well as emotional well-being specific to the presence and severity of neuP. Patients with CTS (n = 108) were subgrouped by the DN4 questionnaire into those without and with neuP. The latter group was further subdivided into mild and moderate/severe neuP using a pain visual analogue scale. N = 32 participants served as healthy controls. All participants underwent a clinical examination, quantitative sensory testing, electrodiagnostic testing (EDT), and skin biopsy to determine the structural integrity of dermal and intraepidermal nerve fibres. Patients also completed questionnaires evaluating symptom severity and functional deficits, pain distribution, sleep quality, and emotional well-being. The overall prevalence of neuP in patients with CTS was 80%, of which 63% had mild neuP. Symptom severity and functional deficits as well as somatosensory dysfunction was more pronounced with the presence and increasing severity of neuP. No difference was identified among patient groups for EDT and nerve fibre integrity on biopsies. The severity of neuP was accompanied by more pronounced deficits in emotional well-being and sleep quality. Intriguingly, extraterritorial spread of symptoms was more prevalent in patients with moderate/severe neuP, indicating the presence of central mechanisms. NeuP is common in patients with CTS, and its severity is related to the extent of somatosensory dysfunction and a compromise of emotional well-being.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, 507.6KB, Terms of use)
-
- Publisher copy:
- 10.1097/j.pain.0000000000002102
Authors
- Publisher:
- Lippincott, Williams & Wilkins
- Journal:
- Pain More from this journal
- Volume:
- 162
- Issue:
- 4
- Pages:
- 1211-1220
- Publication date:
- 2020-10-22
- Acceptance date:
- 2020-09-25
- DOI:
- EISSN:
-
1872-6623
- ISSN:
-
0304-3959
- Language:
-
English
- Keywords:
- Pubs id:
-
1135536
- Local pid:
-
pubs:1135536
- Deposit date:
-
2020-09-29
Terms of use
- Copyright holder:
- Matesanz, L et al.
- Copyright date:
- 2020
- Rights statement:
- Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the International Association for the Study of Pain. This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record