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The structure of arylamine N-acetyltransferase from Mycobacterium smegmatis--an enzyme which inactivates the anti-tubercular drug, isoniazid.

Abstract:

Arylamine N-acetyltransferases which acetylate and inactivate isoniazid, an anti-tubercular drug, are found in mycobacteria including Mycobacterium smegmatis and Mycobacterium tuberculosis. We have solved the structure of arylamine N-acetyltransferase from M. smegmatis at a resolution of 1.7 A as a model for the highly homologous NAT from M. tuberculosis. The fold closely resembles that of NAT from Salmonella typhimurium, with a common catalytic triad and domain structure that is similar to c...

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Publication status:
Published

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Authors


Mushtaq, A More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry, BHF Centre of Research Excellence
Sinclair, J More by this author
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Journal:
Journal of molecular biology
Volume:
318
Issue:
4
Pages:
1071-1083
Publication date:
2002-05-05
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:19a04179-4e6d-44b9-a70f-13d2853c4bc1
Source identifiers:
255836
Local pid:
pubs:255836

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