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An investigation of transmission ratio distortion in the central region of the human MHC.

Abstract:

Transmission ratio distortion (TRD) describes a significant departure from expected Mendelian inheritance ratios that is fundamental to both the biology of reproduction and statistical genetics. The relatively high fetal wastage in humans, with consequent selection of alleles in utero, makes it likely that TRD is prevalent in the human genome. The central region of the human major histocompatibility complex (MHC) is a strong TRD candidate, as it houses a number of immune and regulatory genes ...

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Publication status:
Published

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Publisher copy:
10.1038/sj.gene.6364277

Authors


Hanchard, N More by this author
Rockett, K More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Keating, B More by this author
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Journal:
Genes and immunity
Volume:
7
Issue:
1
Pages:
51-58
Publication date:
2006-01-05
DOI:
EISSN:
1476-5470
ISSN:
1466-4879
URN:
uuid:199f8b04-b5f7-4342-896a-f63d323576f1
Source identifiers:
326082
Local pid:
pubs:326082

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