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Transposon insertion in a serine-specific minor tRNA coding sequence affects intraperitoneal survival of Haemophilus influenzae in the infant rat model.

Abstract:

Due to its lifestyle as a commensal and occasional pathogen in the upper and lower respiratory tracts of humans, Haemophilus influenzae needs to protect itself from endogenously and exogenously generated reactive oxygen species. To better understand the oxygen radical resistance and to investigate a correlation with virulence, randomly generated paraquat-sensitive H. influenzae transposon mutants were analyzed in an infant rat model of infection. Among 25 different paraquat-sensitive mutants ...

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Publication status:
Published

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Publisher copy:
10.1016/j.ijmm.2009.07.001

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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Medicine Division
Role:
Author
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Journal:
International journal of medical microbiology : IJMM
Volume:
300
Issue:
4
Pages:
218-228
Publication date:
2010-04-05
DOI:
EISSN:
1618-0607
ISSN:
1438-4221
URN:
uuid:19944be9-e6c1-49b9-8386-86f74d1b5754
Source identifiers:
115585
Local pid:
pubs:115585

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