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Journal article

Activation rather than Foxp3 expression determines that TGF-β-induced regulatory T cells out-compete naive T cells in dendritic cell clustering.

Abstract:

Regulatory T (Treg) cells are critically important for the maintenance of immunological tolerance. Both centrally arising natural nTreg cells and those emerging in the periphery in response to TGF-β, iTreg cells, play a role in the control of unwanted immune responses. Treg cells adopt multiple mechanisms to inhibit effector T cells, yet it is unclear whether these mechanisms are shared by nTreg cells and iTreg cells alike. Here, we show that iTreg cells, like nTreg cells, are able to out-com...

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Publication status:
Published

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Publisher copy:
10.1002/eji.201142207

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Journal:
European journal of immunology
Volume:
42
Issue:
6
Pages:
1436-1448
Publication date:
2012-06-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:197e5b94-3c0f-4e08-81bc-9889cb3089a4
Source identifiers:
251774
Local pid:
pubs:251774

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