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Journal article

Association mapping in structured populations.

Abstract:

The use, in association studies, of the forthcoming dense genomewide collection of single-nucleotide polymorphisms (SNPs) has been heralded as a potential breakthrough in the study of the genetic basis of common complex disorders. A serious problem with association mapping is that population structure can lead to spurious associations between a candidate marker and a phenotype. One common solution has been to abandon case-control studies in favor of family-based tests of association, such as ...

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Publication status:
Published

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Publisher copy:
10.1086/302959

Authors


Pritchard, JK More by this author
Stephens, M More by this author
Rosenberg, NA More by this author
Donnelly, P More by this author
Journal:
American journal of human genetics
Volume:
67
Issue:
1
Pages:
170-181
Publication date:
2000-07-05
DOI:
EISSN:
1537-6605
ISSN:
0002-9297
URN:
uuid:196a8d7f-5a6b-49ac-8496-6f854f96af12
Source identifiers:
49966
Local pid:
pubs:49966

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