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Human mesenchymal tumour-associated macrophages differentiate into osteoclastic bone-resorbing cells.

Abstract:

The cellular mechanisms which account for the formation of osteoclasts and bone resorption associated with enlarging benign and malignant mesenchymal tumours of bone are uncertain. Osteoclasts are marrow-derived, multinucleated, bone-resorbing cells which express a macrophage phenotype. We have determined whether tumour-associated macrophages (TAMs) isolated from benign and malignant mesenchymal tumours are capable of differentiating into osteoclasts. Macrophages were cultured on both coversl...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Gibbons, CL More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
The Journal of bone and joint surgery. British volume
Volume:
84
Issue:
3
Pages:
452-456
Publication date:
2002-04-05
DOI:
ISSN:
0301-620X
URN:
uuid:19684310-7c1d-49f5-9b87-85765ca584e3
Source identifiers:
103830
Local pid:
pubs:103830

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