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Heterologous amyloid seeding: revisiting the role of acetylcholinesterase in Alzheimer's disease.

Abstract:

Neurodegenerative diseases associated with abnormal protein folding and ordered aggregation require an initial trigger which may be infectious, inherited, post-inflammatory or idiopathic. Proteolytic cleavage to generate vulnerable precursors, such as amyloid-beta peptide (Abeta) production via beta and gamma secretases in Alzheimer's Disease (AD), is one such trigger, but the proteolytic removal of these fragments is also aetiologically important. The levels of Abeta in the central nervous s...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Tahiri-Alaoui, A More by this author
Journal:
PloS one
Volume:
2
Issue:
7
Pages:
e652
Publication date:
2007
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:19667d90-177c-4dca-a526-3d3ba30497df
Source identifiers:
10573
Local pid:
pubs:10573

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