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Journal article

LRRK2 is a component of granular alpha-synuclein pathology in the brainstem of Parkinson's disease.

Abstract:

Classical Parkinson's disease (PD) is characterized by the appearance of Lewy bodies (LBs) in affected brain regions, showing mostly compact alpha-synuclein deposition, in contrast with punctate or granular deposition, hypothesized to represent early stages of aggregation. Leucine-rich repeat kinase 2 (LRRK2) is the commonest mutated gene in inherited and idiopathic PD. LRRK2 mutation carriers display a diverse neuropathology, including alpha-synuclein and tau inclusions, suggesting an upstre...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
Neuropathology and applied neurobiology
Volume:
34
Issue:
3
Pages:
272-283
Publication date:
2008-06-05
DOI:
EISSN:
1365-2990
ISSN:
0305-1846
URN:
uuid:19660d07-86df-496c-9f5f-78307b8f02d0
Source identifiers:
114309
Local pid:
pubs:114309

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