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Targeted deletion of the epididymal receptor HE6 results in fluid dysregulation and male infertility.

Abstract:

Human epididymal protein 6 (HE6; also known as GPR64) is an orphan member of the LNB-7TM (B(2)) subfamily of G-protein-coupled receptors. Family members are characterized by the dual presence of a secretin-like (type II) seven-transmembrane (7TM) domain and a long cell adhesion-like extracellular domain. HE6 is specifically expressed within the efferent ductules and the initial segment of the epididymis, ductal systems involved in spermatozoon maturation. Here, we report that targeted deletio...

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Journal:
Molecular and cellular biology
Volume:
24
Issue:
19
Pages:
8642-8648
Publication date:
2004-10-05
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
URN:
uuid:19659325-9c48-486e-92a6-15bcf62df7a6
Source identifiers:
95874
Local pid:
pubs:95874

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