- Abstract:
-
BACKGROUND: High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are randomly assigned at meiosis, are independent of non-genetic confounding, and are unmodified by disease processes, mendelian randomisation can be used to test the hypothesis that the association of a plasma biomarker with disease is causal. METHODS: We performed two mendelian randomisation analyses. First, w...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/s0140-6736(12)60312-2
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- Journal:
- Lancet
- Volume:
- 380
- Issue:
- 9841
- Pages:
- 572-580
- Publication date:
- 2012-08-05
- DOI:
- EISSN:
-
1474-547X
- ISSN:
-
0140-6736
- URN:
-
uuid:19642ec3-669e-4d8d-8886-94be8af727db
- Source identifiers:
-
332878
- Local pid:
- pubs:332878
- Copyright date:
- 2012
Journal article
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study.
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