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Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study.

Abstract:

BACKGROUND: High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are randomly assigned at meiosis, are independent of non-genetic confounding, and are unmodified by disease processes, mendelian randomisation can be used to test the hypothesis that the association of a plasma biomarker with disease is causal. METHODS: We performed two mendelian randomisation analyses. First, w...

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Publication status:
Published

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Authors


Voight, BF More by this author
Peloso, GM More by this author
Orho-Melander, M More by this author
Frikke-Schmidt, R More by this author
Barbalic, M More by this author
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Journal:
Lancet
Volume:
380
Issue:
9841
Pages:
572-580
Publication date:
2012-08-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:19642ec3-669e-4d8d-8886-94be8af727db
Source identifiers:
332878
Local pid:
pubs:332878

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