- Abstract:
-
Alphabeta T-cell receptors (TcRs) play a central role in cellular immune response. They are members of the Ig superfamily, with extracellular regions of the alpha and beta chains each comprising a V-type domain and a C-type domain. We have determined the ectodomain structure of an alphabeta TcR, which recognizes the autoantigen myelin basic protein. The 2.0-A-resolution structure reveals canonical main-chain conformations for the V(alpha), V(beta), and C(beta) domains, but the C(alpha) domain...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.jmb.2010.05.053
-
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- Journal:
- Journal of molecular biology
- Volume:
- 400
- Issue:
- 4
- Pages:
- 828-837
- Publication date:
- 2010-07-05
- DOI:
- EISSN:
-
1089-8638
- ISSN:
-
0022-2836
- URN:
-
uuid:1963c30c-ebd9-40e6-8f07-f9f703b4e4b5
- Source identifiers:
-
65284
- Local pid:
- pubs:65284
- Copyright date:
- 2010
Journal article
An alternative conformation of the T-cell receptor alpha constant region.
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