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An alternative conformation of the T-cell receptor alpha constant region.

Abstract:

Alphabeta T-cell receptors (TcRs) play a central role in cellular immune response. They are members of the Ig superfamily, with extracellular regions of the alpha and beta chains each comprising a V-type domain and a C-type domain. We have determined the ectodomain structure of an alphabeta TcR, which recognizes the autoantigen myelin basic protein. The 2.0-A-resolution structure reveals canonical main-chain conformations for the V(alpha), V(beta), and C(beta) domains, but the C(alpha) domain...

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Publication status:
Published

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Publisher copy:
10.1016/j.jmb.2010.05.053

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience, Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Role:
Author
Journal:
Journal of molecular biology
Volume:
400
Issue:
4
Pages:
828-837
Publication date:
2010-07-05
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:1963c30c-ebd9-40e6-8f07-f9f703b4e4b5
Source identifiers:
65284
Local pid:
pubs:65284

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