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Oxidative degradation of bilirubin produces vasoactive compounds.

Abstract:

Subarachnoid haemorrhage is often followed by haemolysis and concomitant oxidative stress, and is frequently complicated by pathological vasoconstriction or cerebral vasospasm. It is known that upregulation of haem oxygenase (HO-1) is induced by oxidative stress and results in release of biliverdin and bilirubin (BR), which are scavengers of reactive oxygen species (ROS). Here we report biomimetic studies aimed at modelling pathological conditions leading to oxidative degradation of BR. Oxida...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Harris, DA More by this author
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Journal:
European journal of biochemistry / FEBS
Volume:
267
Issue:
24
Pages:
7094-7101
Publication date:
2000-12-05
DOI:
EISSN:
1432-1033
ISSN:
0014-2956
URN:
uuid:19596acc-0f06-4294-9c2c-624898fd5c00
Source identifiers:
31789
Local pid:
pubs:31789

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