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Allosteric beta-propeller signalling in TolB and its manipulation by translocating colicins.

Abstract:

The Tol system is a five-protein assembly parasitized by colicins and bacteriophages that helps stabilize the Gram-negative outer membrane (OM). We show that allosteric signalling through the six-bladed beta-propeller protein TolB is central to Tol function in Escherichia coli and that this is subverted by colicins such as ColE9 to initiate their OM translocation. Protein-protein interactions with the TolB beta-propeller govern two conformational states that are adopted by the distal N-termin...

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Publication status:
Published

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Publisher copy:
10.1038/emboj.2009.224

Authors


Bonsor, DA More by this author
Vankemmelbeke, M More by this author
Krachler, AM More by this author
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Journal:
The EMBO journal
Volume:
28
Issue:
18
Pages:
2846-2857
Publication date:
2009-09-05
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:195879d3-4b2f-4546-97f4-5512c6225334
Source identifiers:
310205
Local pid:
pubs:310205

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