- Abstract:
-
Antibodies to selected Plasmodium falciparum merozoite antigens are often reported to be associated with protection from malaria in one epidemiological cohort, but not in another. Here, we sought to understand this paradox by exploring the hypothesis that a threshold concentration of antibodies is necessary for protection. We analyzed data from two independent cohorts along the Kenyan coast, one in which antibodies to AMA1, MSP-2 and MSP-3 were associated with protection from malaria (Chonyi)...
Expand abstract - Publisher copy:
- 10.1016/j.vaccine.2013.06.042
-
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- Journal:
- Vaccine
- Volume:
- 31
- Issue:
- 37
- Pages:
- 3936-3942
- Publication date:
- 2013-08-20
- DOI:
- EISSN:
-
1873-2518
- ISSN:
-
0264-410X
- URN:
-
uuid:19574b18-0a2b-49ec-bd31-43c79299e4c1
- Source identifiers:
-
419177
- Local pid:
- pubs:419177
- Language:
- English
- Keywords:
- Copyright date:
- 2013
Journal article
A threshold concentration of anti-merozoite antibodies is required for protection from clinical episodes of malaria
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