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ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection.

Abstract:

Vertebrate DNA can be chemically modified by methylation of the 5 position of the cytosine base in the context of CpG dinucleotides. This modification creates a binding site for MBD (methyl-CpG-binding domain) proteins which target chromatin-modifying activities that are thought to contribute to transcriptional repression and maintain heterochromatic regions of the genome. In contrast with DNA methylation, which is found broadly across vertebrate genomes, non-methylated DNA is concentrated in...

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Publication status:
Published

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Publisher copy:
10.1042/bst20130028

Authors


Blackledge, NP More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Journal:
Biochemical Society transactions
Volume:
41
Issue:
3
Pages:
727-740
Publication date:
2013-06-05
DOI:
EISSN:
1470-8752
ISSN:
0300-5127
URN:
uuid:194ec326-8549-4a6f-a9fd-66f9001fc79c
Source identifiers:
401417
Local pid:
pubs:401417

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