- Abstract:
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The proneural transcription factor Ascl1 coordinates gene expression in both proliferating and differentiating progenitors along the neuronal lineage. Here, we used a cellular model of neurogenesis to investigate how Ascl1 interacts with the chromatin landscape to regulate gene expression when promoting neuronal differentiation. We find that Ascl1 binding occurs mostly at distal enhancers and is associated with activation of gene transcription. Surprisingly, the accessibility of Ascl1 to its ...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 3.3MB)
-
- Publisher copy:
- 10.1016/j.celrep.2015.02.025
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- Publisher:
- Elsevier Publisher's website
- Journal:
- Cell Reports Journal website
- Volume:
- 10
- Issue:
- 9
- Pages:
- 1544-1556
- Publication date:
- 2015-03-05
- DOI:
- EISSN:
-
2211-1247
- ISSN:
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2211-1247
- URN:
-
uuid:19460b06-8d12-404f-b24f-1203923061b8
- Source identifiers:
-
508502
- Local pid:
- pubs:508502
- Copyright holder:
- Raposo et al.
- Copyright date:
- 2015
- Notes:
- Copyright © 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
Journal article
Ascl1 coordinately regulates gene expression and the chromatin landscape during neurogenesis
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