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Ascl1 coordinately regulates gene expression and the chromatin landscape during neurogenesis

Abstract:

The proneural transcription factor Ascl1 coordinates gene expression in both proliferating and differentiating progenitors along the neuronal lineage. Here, we used a cellular model of neurogenesis to investigate how Ascl1 interacts with the chromatin landscape to regulate gene expression when promoting neuronal differentiation. We find that Ascl1 binding occurs mostly at distal enhancers and is associated with activation of gene transcription. Surprisingly, the accessibility of Ascl1 to its ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.celrep.2015.02.025

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Role:
Editor
Publisher:
Elsevier Publisher's website
Journal:
Cell Reports Journal website
Volume:
10
Issue:
9
Pages:
1544-1556
Publication date:
2015-03-05
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
URN:
uuid:19460b06-8d12-404f-b24f-1203923061b8
Source identifiers:
508502
Local pid:
pubs:508502

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