Journal article icon

Journal article

Continuing postischemic neuronal death in CA1: influence of ischemia duration and cytoprotective doses of NBQX and SNX-111 in rats.

Abstract:

BACKGROUND AND PURPOSE: Transient forebrain ischemia results in a 24- to 72-hour delayed loss of CA1 neurons. Previous work has not assessed whether insult durations can vary the degree and maturation rate of CA1 injury and whether there are different ultrastructural features of death after brief or severe ischemia. We also tested whether known cytoprotective drugs achieve permanent or transient neuroprotection. METHODS: In the first experiment, ischemia was induced for 5, 15, or 30 minutes w...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1161/01.str.30.3.662

Authors


Colbourne, F More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Stroke and Geratology
Clemens, JA More by this author
Journal:
Stroke; a journal of cerebral circulation
Volume:
30
Issue:
3
Pages:
662-668
Publication date:
1999-03-05
DOI:
EISSN:
1524-4628
ISSN:
0039-2499
URN:
uuid:194305cd-092e-4656-937a-a70c5ca543d6
Source identifiers:
79171
Local pid:
pubs:79171

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP