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Structure of a VP1-VP3 complex suggests how birnaviruses package the VP1 polymerase.

Abstract:

Infectious pancreatic necrosis virus (IPNV), a member of the family Birnaviridae, infects young salmon, with a severe impact on the commercial sea farming industry. Of the five mature proteins encoded by the IPNV genome, the multifunctional VP3 has an essential role in morphogenesis; interacting with the capsid protein VP2, the viral double-stranded RNA (dsRNA) genome and the RNA-dependent RNA polymerase VP1. Here we investigate one of these VP3 functions and present the crystal structure of ...

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Publication status:
Published

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Publisher copy:
10.1128/jvi.02939-12

Authors


Graham, SC More by this author
Bamford, DH More by this author
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Journal:
Journal of virology
Volume:
87
Issue:
6
Pages:
3229-3236
Publication date:
2013-03-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:192a5b64-ccbd-4450-9783-a0fc1152b2bc
Source identifiers:
369840
Local pid:
pubs:369840

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