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Pancreatic stellate cells radioprotect pancreatic cancer cells through β1-integrin signaling.

Abstract:

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a strong desmoplastic reaction where the stromal compartment often accounts for more than half of the tumor volume. Pancreatic stellate cells (PSC) are a central mediator of desmoplasia. There is increasing evidence that desmoplasia is contributing to the poor therapeutic response of PDAC. We show that PSCs promote radioprotection and stimulate proliferation in pancreatic cancer cells (PCC) in direct coculture. Our in vivo studies sh...

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Publication status:
Published

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Authors


Mantoni, TS More by this author
Lunardi, S More by this author
Al-Assar, O More by this author
Masamune, A More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Journal:
Cancer research
Volume:
71
Issue:
10
Pages:
3453-3458
Publication date:
2011-05-05
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:1924920f-74aa-4a86-a95e-62ccd02584b0
Source identifiers:
138857
Local pid:
pubs:138857

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