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Pancreatic stellate cells radioprotect pancreatic cancer cells through β1-integrin signaling.

Abstract:

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a strong desmoplastic reaction where the stromal compartment often accounts for more than half of the tumor volume. Pancreatic stellate cells (PSC) are a central mediator of desmoplasia. There is increasing evidence that desmoplasia is contributing to the poor therapeutic response of PDAC. We show that PSCs promote radioprotection and stimulate proliferation in pancreatic cancer cells (PCC) in direct coculture. Our in vivo studies sh...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Journal:
Cancer research
Volume:
71
Issue:
10
Pages:
3453-3458
Publication date:
2011-05-01
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
Source identifiers:
138857
Language:
English
Keywords:
Pubs id:
pubs:138857
UUID:
uuid:1924920f-74aa-4a86-a95e-62ccd02584b0
Local pid:
pubs:138857
Deposit date:
2012-12-19

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