Journal article
The arrhythmogenic cardiotoxicity of the quinoline and structurally related antimalarial drugs: a systematic review
- Abstract:
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Background Several quinoline and structurally related antimalarial drugs are associated with cardiovascular side effects, particularly hypotension and electrocardiographic QT interval prolongation. A prolonged QT interval is a sensitive but not specific risk marker for the development of Torsade de Pointes—a potentially lethal polymorphic ventricular tachyarrhythmia. The increasing use of quinoline and structurally related antimalarials in mass treatments to eliminate mal...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 742.9KB, Terms of use)
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- Publisher copy:
- 10.1186/s12916-018-1188-2
Authors
+ University of Oxford
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- Funding agency for:
- Chan, X
- Grant:
- HerbertHuntTravellingScholarship
- Jill
+ Medical Research Council
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- Funding agency for:
- Chan, X
- Grant:
- HerbertHuntTravellingScholarship
- Jill
+ Wellcome Trust
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- Funding agency for:
- Chan, X
- White, N
- Grant:
- HerbertHuntTravellingScholarship
- Jill
- Principal Research Fellow: 107886/Z/15/Z
- Publisher:
- BioMed Central
- Journal:
- BMC Medicine More from this journal
- Volume:
- 16
- Issue:
- 200
- Pages:
- 1-13
- Publication date:
- 2018-11-07
- Acceptance date:
- 2018-10-09
- DOI:
- EISSN:
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1741-7015
- ISSN:
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1741-7015
- Keywords:
- Pubs id:
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pubs:925513
- UUID:
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uuid:190c2492-4255-4276-904c-bb1c654b3772
- Local pid:
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pubs:925513
- Source identifiers:
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925513
- Deposit date:
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2018-10-09
Terms of use
- Copyright holder:
- Haeusler et al
- Copyright date:
- 2018
- Notes:
- © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated
- Licence:
- CC Attribution (CC BY)
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