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Intercellular adhesion molecule-1 is an endothelial cell adhesion receptor for Plasmodium falciparum.

Abstract:

The primary event in the pathogenesis of severe malaria in Plasmodium falciparum infection is thought to be adherence of trophozoite- and schizont-infected erythrocytes to capillary endothelium, a process called sequestration. Identifying the endothelial molecules used as receptors is an essential step in understanding this disease process. Recent work implicates the membrane glycoprotein CD36 (platelet glycoprotein IV; refs 2-5) and the multi-functional glycoprotein thrombospondin as recepto...

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Publication status:
Published

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Publisher copy:
10.1038/341057a0

Authors


Berendt, AR More by this author
Simmons, DL More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Journal:
Nature
Volume:
341
Issue:
6237
Pages:
57-59
Publication date:
1989-09-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:19031b2e-727f-4963-8316-b90fdd78b0fd
Source identifiers:
5702
Local pid:
pubs:5702

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