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Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity

Abstract:

Identification of alterations in the cellular composition of the human immune system is key to understanding the autoimmune process. Recently, a subset of FOXP3+ cells with low CD25 expression was found to be increased in peripheral blood from systemic lupus erythematosus (SLE) patients, although its functional significance remains controversial. Here we find in comparisons with healthy donors that the frequency of FOXP3+ cells within CD127lowCD25low CD4+ T cells (here defined as CD25lowFOX...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.jaut.2017.07.009

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Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
Role:
Author
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Department:
Oxford, MSD, NDM
Role:
Author
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Funding agency for:
Ferreira, RC
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Grant:
Cambridge Biomedical Research Centre
Publisher:
Elsevier Publisher's website
Journal:
Journal of Autoimmunity Journal website
Volume:
84
Pages:
75-86
Publication date:
2017-07-23
Acceptance date:
2017-07-13
DOI:
ISSN:
0896-8411
Pubs id:
pubs:708914
URN:
uri:19018978-276a-42ae-8be9-ae35476f0794
UUID:
uuid:19018978-276a-42ae-8be9-ae35476f0794
Local pid:
pubs:708914

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