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Journal article

Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity

Abstract:

Identification of alterations in the cellular composition of the human immune system is key to understanding the autoimmune process. Recently, a subset of FOXP3+ cells with low CD25 expression was found to be increased in peripheral blood from systemic lupus erythematosus (SLE) patients, although its functional significance remains controversial. Here we find in comparisons with healthy donors that the frequency of FOXP3+ cells within CD127lowCD25low CD4+ T cells (here defined as CD25lowFOX...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.jaut.2017.07.009

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
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Funding agency for:
Ferreira, R
Grant:
Post-doctoral fellowship (2-APF-2017-420-A-N
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Grant:
Diabetes
InflammationLaboratoryfromthe 549JDRF(9-2011-253
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Grant:
Cambridge Biomedical Research Centre
Publisher:
Elsevier Publisher's website
Journal:
Journal of Autoimmunity Journal website
Volume:
84
Pages:
75-86
Publication date:
2017-07-23
Acceptance date:
2017-07-13
DOI:
ISSN:
0896-8411
Keywords:
Pubs id:
pubs:708914
UUID:
uuid:19018978-276a-42ae-8be9-ae35476f0794
Local pid:
pubs:708914
Deposit date:
2017-07-21

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