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Opiates control ACTH through a noradrenergic mechanism.

Abstract:
The administration of 16 mg of naloxone to six normal male subjects produced a significant rise in plasma cortisol. Pre-treatment with the noradrenergic α1-antagonist, thymoxamine 0.2 mg/kg, blocked this rise. It is suggested that opiate inhibition of the pituitary-adrenal axis is mediated via a noradrenergic pathway.
Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Besser, GM More by this author
Journal:
Clinical endocrinology
Volume:
17
Issue:
3
Pages:
287-290
Publication date:
1982-09-05
DOI:
EISSN:
1365-2265
ISSN:
0300-0664
URN:
uuid:18fb81ab-06b2-4ac4-aac0-df3416054e60
Source identifiers:
138705
Local pid:
pubs:138705

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