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A comparison of two DNA probes, one specific for Plasmodium falciparum and one with wider reactivity, in the diagnosis of malaria.

Abstract:

The sensitivity and specificity of 2 probes for the detection of malarial infection was studied. 399 blood samples from Gambian children were tested in a deoxyribonucleic acid (DNA) hybridization assay, and the results compared with the microscopical findings from thick blood films. 8 additional pure Plasmodium malariae and 14 pure P. vivax samples were also assayed. One probe, containing a 21 base pair tandem repeat and highly specific for P. falciparum, detected this species in all except 2...

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Publication status:
Published

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Authors


Holmberg, M More by this author
Vaidya, AB More by this author
Shenton, FC More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Greenwood, BM More by this author
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Journal:
Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume:
84
Issue:
2
Pages:
202-205
Publication date:
1990
DOI:
EISSN:
1878-3503
ISSN:
0035-9203
URN:
uuid:18ece636-abec-4353-b924-abdcb907cdfe
Source identifiers:
102338
Local pid:
pubs:102338

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