Contribution of base lesions to radiation-induced clustered DNA damage: implication for models of radiation response.

Journal article

Biophysical modeling of radiation-induced DNA damage shows that significant yields of clustered DNA damage are formed after energy deposition by a single radiation track. To date, the majority of studies on radiation-induced DNA damage in cells have concentrated on determination of the yields of single- and double-strand breaks (DSBs), the latter representing one type of clustered DNA damage. It was recognized, however, that clustered DNA damage, which does not contain a DSB, might contain a combination of DNA base lesions and single-strand breaks in proximity. This mini-review discusses some of the recent experimental data confirming the induction of non-DSB, clustered DNA damage by radiation.

Authors: Jenner, T; Fulford, J; O'Neill, P

• Publication status: Published
• Journal: Radiation research
• Volume: 156
• Issue: 5 Pt 2
• Pages: 590-593
• Publication date: 2001-11-01
• DOI: 10.1667/0033-7587(2001)156[0590:cobltr]2.0.co;2
• EISSN: 1938-5404
• ISSN: 0033-7587
• Language: English
• Keywords: DNA; Models, Biological; Radiation, Ionizing; Plasmids; Humans; DNA Damage