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Contribution of base lesions to radiation-induced clustered DNA damage: implication for models of radiation response.

Abstract:

Biophysical modeling of radiation-induced DNA damage shows that significant yields of clustered DNA damage are formed after energy deposition by a single radiation track. To date, the majority of studies on radiation-induced DNA damage in cells have concentrated on determination of the yields of single- and double-strand breaks (DSBs), the latter representing one type of clustered DNA damage. It was recognized, however, that clustered DNA damage, which does not contain a DSB, might contain a ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
Journal:
Radiation research
Volume:
156
Issue:
5 Pt 2
Pages:
590-593
Publication date:
2001-11-05
DOI:
EISSN:
1938-5404
ISSN:
0033-7587
URN:
uuid:18e04ff9-262b-42b5-8f96-1be59e289058
Source identifiers:
131352
Local pid:
pubs:131352

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