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Effect of L-NMMA, cromakalim, and glibenclamide on cerebral blood flow in hypercapnia and hypoxia.

Abstract:

Sulfonylureas reduce cerebral blood flow (CBF) during hypoxia but not during hypercapnia, whereas blockers of nitric oxide (NO) synthesis reduce hypercapnic CBF. However, the effect of NO blockers on hypoxic CBF is uncertain. CBF was measured in the cortex of 51 enflurane-anesthetized rats by the hydrogen clearance technique during eucapnia, hypercapnia (arterial PCO2 65 Torr), and hypoxia (arterial PO2 40 Torr). CBF increased twofold in both hypercapnia and hypoxia from eucapnia. Intracortic...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
American journal of physiology
Volume:
269
Issue:
3 Pt 2
Pages:
H916-H922
Publication date:
1995-09-01
ISSN:
0002-9513
Source identifiers:
115248
Language:
English
Keywords:
Pubs id:
pubs:115248
UUID:
uuid:18de2c53-497b-41fe-8a55-acf60aa4b47c
Local pid:
pubs:115248
Deposit date:
2012-12-19

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