Cytokine regulation of the epidermal barrier.

Journal article

Studies published in recent years have highlighted the role of epidermal barrier defects in both atopic skin disease and the development of broader allergic manifestations. While genetic determinants of barrier function are important, it is clear that local acquired effects are also involved in disease pathogenesis. In this review, we aimed to summarize the known influences of cytokines abundantly expressed during atopic skin disease on components of epidermal barrier integrity and function.

Authors: Gutowska-Owsiak, D; Ogg, G

• Publication status: Published
• Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
• Volume: 43
• Issue: 6
• Pages: 586-598
• Publication date: 2013-06-01
• DOI: 10.1111/cea.12023
• EISSN: 1365-2222
• ISSN: 0954-7894
• Language: English
• Keywords: Intercellular Junctions; Water; Skin; Keratinocytes; Signal Transduction; Cell Differentiation; Cytokines; Animals; Peptide Hydrolases; Lipid Metabolism; Epidermis; Inflammation; Intermediate Filament Proteins; Cell Adhesion Molecules; Humans