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Journal article

Immune selection and genetic sequence variation in core and envelope regions of hepatitis C virus.

Abstract:

How Hepatitis C Virus (HCV) causes persistent infection is unknown. One hypothesis is that HCV evades the host immune response through mutation in immune epitopes. We have investigated mutations in the HCV genome to see if they cluster within immune epitopes; and we have studied the effect of antibody deficiency on mutation rates. We studied patients with chronic hepatitis C, 3 with antibody deficiency and 3 with normal immunity. Regions of the core and envelope genes of HCV, encoding cytotox...

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Publication status:
Published

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Publisher copy:
10.1002/hep.510300403

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Journal:
Hepatology (Baltimore, Md.)
Volume:
30
Issue:
4
Pages:
1037-1044
Publication date:
1999-10-01
DOI:
EISSN:
1527-3350
ISSN:
0270-9139
Source identifiers:
66413

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