Journal article
Are we on our way to achieving the 2020 goals for schistosomiasis morbidity control using current World Health Organization guidelines?
- Abstract:
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Background
Schistosomiasis remains an endemic parasitic disease affecting millions of people around the world. The World Health Organization (WHO) has set goals of controlling morbidity to be reached by 2020, along with elimination as a public health problem in certain regions by 2025. Mathematical models of parasite transmission and treatment impact have been developed to assist in controlling the morbidity caused by schistosomiasis. These models can inform and guide implementation policy for mass drug administration programs, and help design monitoring and evaluation activities.
Methods
We use these models to predict whether the guidelines set by the WHO are on track for achieving their 2020 goal for the control of morbidity, specifically for Schistosoma mansoni. We examine whether programmatic adaptations; namely increases in treatment coverage and/or expansion to adult inclusion in treatment, will improve the likelihood of reaching the WHO goals.
Results
We find that in low-prevalence settings, the goals are likely to be attainable under current WHO guidelines, but in moderate to high-prevalence settings, the goals are less likely to be achieved unless treatment coverage is increased and expanded to at least 85% for school-aged children and 40% for adults.
Conclusions
To improve the likelihood of reaching the WHO goals, programmatic adaptations are required, particularly for moderate- to high-prevalence settings. Furthermore, improvements in adherence to treatment, potential development of candidate vaccines, and enhanced snail control and WASH (water, sanitation, and hygiene) measures will all assist in achieving the goals.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 2.7MB, Terms of use)
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- Publisher copy:
- 10.1093/cid/ciy001
Authors
- Publisher:
- Oxford University Press
- Journal:
- Clinical Infectious Diseases More from this journal
- Volume:
- 66
- Issue:
- S4
- Pages:
- S245-S252
- Publication date:
- 2018-06-01
- Acceptance date:
- 2018-01-06
- DOI:
- EISSN:
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1537-6591
- ISSN:
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1058-4838
- Pmid:
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29860290
- Language:
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English
- Keywords:
- Pubs id:
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pubs:856578
- UUID:
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uuid:18d0e923-3fc5-4e46-b8e6-718c23e16e0f
- Local pid:
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pubs:856578
- Source identifiers:
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856578
- Deposit date:
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2018-06-09
Terms of use
- Copyright holder:
- Turner et al
- Copyright date:
- 2018
- Notes:
- © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: 10.1093/cid/ciy001
- Licence:
- CC Attribution (CC BY)
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