From hype to hope? A journey through the genetics of Type 2 diabetes

Journal article

Recent advances in genetic analysis have enabled researchers to perform genome-wide surveys for common DNA sequence variants associated with risk of Type 2 diabetes and related traits. Over the past 4 years, these endeavours have extended the number of proven Type 2 diabetes-susceptibility loci from a handful to the current total of over 40. Each of these loci provides an opportunity to uncover insights into the biology of glucose regulation and the pathogenesis of Type 2 diabetes, insights which should support clinical translation to identify novel ways of treating and preventing disease. Here, I describe (i) progress in identification of diabetes-susceptibility loci; (ii) biological insights that have been gained in the relatively short period since these loci were discovered; and (iii) the challenges that need to be addressed if we are to maximize the translational benefits of this research. © 2011 The Author. Diabetic Medicine © 2011 Diabetes UK.

Authors: Mccarthy, M

• Journal: Diabetic Medicine
• Volume: 28
• Issue: 2
• Pages: 132-140
• Publication date: 2011-02-01
• DOI: 10.1111/j.1464-5491.2010.03194.x
• EISSN: 1464-5491
• ISSN: 0742-3071
• Language: English
• Keywords: Genetics; Association; Genome-wide association studies; Physiology; Type 2 diabetes