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SYNTHESIS OF THE POTENT ANTIVIRAL OXETANE NUCLEOSIDE EPINOROXETANOCIN FROM D-LYXONOLACTONE

Abstract:
A short synthesis of epinoroxetanocin [9-(β-D-threo-oxetanosyl)adenine], free from its α-anomer, from D-lyxonolactone is described. The X-ray crystal structure of a benzylidene-protected derivative of epinoroxetanocin is reported. A comparison of the in vitro activity against HIV-1 of oxetanocin, noroxetanocin and epinoroxetanocin as anti-viral agents is given. © 1990.
Publication status:
Published

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Journal:
TETRAHEDRON-ASYMMETRY
Volume:
1
Issue:
8
Pages:
527-530
Publication date:
1990-01-01
DOI:
EISSN:
1362-511X
ISSN:
0957-4166
URN:
uuid:18cbef90-abf2-48f3-982e-23d6f43081a6
Source identifiers:
43339
Local pid:
pubs:43339
Language:
English

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