- A short synthesis of epinoroxetanocin [9-(β-D-threo-oxetanosyl)adenine], free from its α-anomer, from D-lyxonolactone is described. The X-ray crystal structure of a benzylidene-protected derivative of epinoroxetanocin is reported. A comparison of the in vitro activity against HIV-1 of oxetanocin, noroxetanocin and epinoroxetanocin as anti-viral agents is given. © 1990.
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SYNTHESIS OF THE POTENT ANTIVIRAL OXETANE NUCLEOSIDE EPINOROXETANOCIN FROM D-LYXONOLACTONE
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