An observational study of children with sickle cell disease in Kilifi, Kenya.

Journal article

Globally, sickle cell disease (SCD) has its highest prevalence and worst prognosis in sub-Saharan Africa. Nevertheless, relatively few studies describe the clinical characteristics of children with SCD in this region. We conducted a prospective observational study of children with SCD attending a specialist out-patient clinic in Kilifi, Kenya. A total of 124 children (median age 6.3 years) were included in the study. Splenomegaly was present in 41 (33%) subjects and hepatomegaly in 25 (20%), ...

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Authors: Sadarangani, M; Makani, J; Komba, A; Ajala-Agbo, T; Newton, C

• Publication status: Published
• Journal: British journal of haematology
• Volume: 146
• Issue: 6
• Pages: 675-682
• Publication date: 2009-09-01
• DOI: 10.1111/j.1365-2141.2009.07771.x
• EISSN: 1365-2141
• ISSN: 0007-1048
• Language: English
• Keywords: Child; Adolescent; Child, Preschool; Malaria, Falciparum; Bilirubin; Splenomegaly; Infant; Aspartate Aminotransferases; Female; Male; Hepatomegaly; Anthropometry; Kenya; Humans; Anemia, Sickle Cell; Cohort Studies; Hemoglobins