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HIV-2 capsids distinguish high and low virus load patients in a West African community cohort.

Abstract:

HIV-2 causes AIDS similar to HIV-1, however a considerable proportion of HIV-2 infected patients show no disease and have low plasma virus load (VL). An analysis of HIV-2 capsid (p26) variation demonstrated that proline at p26 positions 119, 159 and 178 are more frequent in lower VL subjects while non-proline residues at all three sites are more frequent in subjects with high VL. In vitro replication levels of viruses bearing changes at the three sites suggested that these three residues infl...

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Publication status:
Published

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Authors


Onyango, CO More by this author
Leligdowicz, A More by this author
Yokoyama, M More by this author
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Journal:
Vaccine
Volume:
28 Suppl 2
Issue:
SUPPL. 2
Pages:
B60-B67
Publication date:
2010-05-05
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
URN:
uuid:18b38f20-7fcc-4430-9a39-cd515afdbcf8
Source identifiers:
176641
Local pid:
pubs:176641

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