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Effect of intravenous nitrates on mortality in acute myocardial infarction: an overview of the randomised trials.

Abstract:

About 2000 patients have been randomised in ten trials of intravenous nitroglycerin or nitroprusside in acute myocardial infarction. Taken separately, the individual trials have all been too small to provide a reliable estimate of the effects of treatment on mortality, but collectively they provide strong evidence of benefit. In total there have been 136 nitrate and 193 control deaths, and an appropriate overview of the separate trial results indicated a "typical" reduction of 35% (SD 10) in ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit, BHF Centre of Research Excellence
MacMahon, S More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit
Journal:
Lancet (London, England)
Volume:
1
Issue:
8594
Pages:
1088-1092
Publication date:
1988-05-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:18b0ac0d-a65d-40df-a7b3-f5914e5ef524
Source identifiers:
35261
Local pid:
pubs:35261

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