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Journal article

The use of HLA class I tetramers to design a vaccination strategy for melanoma patients.

Abstract:

Progress in human tumor immunology has recently been accelerated by new assays for antigen-specific cytotoxic T lymphocytes (CTLs). We have used tetrameric MHC class I complexes (tetramers) to study melanoma-specific CTLs both in vivo and in vitro, and have utilized the results to optimize vaccination strategies for patients. Tetramers have provided some of the best evidence to date that CTL responses against melanoma antigens arise spontaneously in patients. However, CTL responses to common ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, Biomedical Research Centre
Role:
Author
Journal:
Immunological reviews
Volume:
188
Issue:
1
Pages:
155-163
Publication date:
2002-10-05
DOI:
EISSN:
1600-065X
ISSN:
0105-2896
URN:
uuid:18acbb75-8190-4790-87e8-50d924922b3c
Source identifiers:
32254
Local pid:
pubs:32254

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