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Proteomic analysis of integrin alphaIIbbeta3 outside-in signaling reveals Src-kinase-independent phosphorylation of Dok-1 and Dok-3 leading to SHIP-1 interactions.

Abstract:

BACKGROUND AND OBJECTIVES: Outside-in integrin alphaIIbbeta3 signaling involves a series of tyrosine kinase reactions that culminate in platelet spreading on fibrinogen. The aim of this study was to identify novel tyrosine phosphorylated signaling proteins downstream of alphaIIbbeta3, and explore their role in platelet signaling. METHODS AND RESULTS: Utilizing proteomics to search for novel platelet proteins that contribute to outside-in signaling by the integrin alphaIIbbeta3, we identified ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


Antrobus, R More by this author
Severin, S More by this author
Parguiña, AF More by this author
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Spanish Ministry of Science and Innovation More from this funder
Galician Government More from this funder
British Heart Foundation More from this funder
Oxford Glycobiology Institute More from this funder
Publisher:
Wiley Publisher's website
Journal:
Journal of thrombosis and haemostasis : JTH Journal website
Volume:
7
Issue:
10
Pages:
1718-1726
Publication date:
2009-10-05
DOI:
EISSN:
1538-7836
ISSN:
1538-7933
URN:
uuid:18acb945-7ded-46c7-92ad-36a681652cfe
Source identifiers:
100360
Local pid:
pubs:100360

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