- Abstract:
-
Transmission of hemorrhagic fever New World arenaviruses from their rodent reservoirs to human populations poses substantial public health and economic dangers. These zoonotic events are enabled by the specific interaction between the New World arenaviral attachment glycoprotein, GP1, and cell surface human transferrin receptor (hTfR1). Here, we present the structural basis for how a mouse-derived neutralizing antibody (nAb), OD01, disrupts this interaction by targeting the receptor-binding s...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
- Files:
-
-
(pdf, 135.0KB)
-
- Publisher copy:
- 10.1073/pnas.1702127114
-
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- Publisher:
- National Academy of Sciences Publisher's website
- Journal:
- Proceedings of the National Academy of Sciences Journal website
- Volume:
- 114
- Issue:
- 27
- Pages:
- 7031–7036
- Publication date:
- 2017-06-19
- Acceptance date:
- 2017-05-23
- DOI:
- ISSN:
-
1091-6490
- Pubs id:
-
pubs:701540
- URN:
-
uri:189ff624-d2c8-478b-8c14-8690aa4d9659
- UUID:
-
uuid:189ff624-d2c8-478b-8c14-8690aa4d9659
- Local pid:
- pubs:701540
- Language:
- English
- Keywords:
- Copyright holder:
- Zeltina et al.
- Copyright date:
- 2017
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from National Academy of Sciences at: doi: 10.1073/pnas.1702127114
Journal article
Convergent immunological solutions to Argentine hemorrhagic fever virus neutralization
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