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Convergent immunological solutions to Argentine hemorrhagic fever virus neutralization

Abstract:

Transmission of hemorrhagic fever New World arenaviruses from their rodent reservoirs to human populations poses substantial public health and economic dangers. These zoonotic events are enabled by the specific interaction between the New World arenaviral attachment glycoprotein, GP1, and cell surface human transferrin receptor (hTfR1). Here, we present the structural basis for how a mouse-derived neutralizing antibody (nAb), OD01, disrupts this interaction by targeting the receptor-binding s...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1073/pnas.1702127114

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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Structural Biology
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Structural Biology
Role:
Author
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Funding agency for:
Zeltina, A
Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
114
Issue:
27
Pages:
7031–7036
Publication date:
2017-06-19
Acceptance date:
2017-05-23
DOI:
ISSN:
1091-6490
Pubs id:
pubs:701540
URN:
uri:189ff624-d2c8-478b-8c14-8690aa4d9659
UUID:
uuid:189ff624-d2c8-478b-8c14-8690aa4d9659
Local pid:
pubs:701540

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