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Vascular endothelial growth factor signalling in endothelial cell survival: a role for NFkappaB.

Abstract:

Angiogenesis is the development of blood capillaries from pre-existing vessels. Vascular endothelial growth factor (VEGF) is a key regulator of vessel growth and regression, and acts as an endothelial survival factor by protecting endothelial cells from apoptosis. Many genes involved in cell proliferation and apoptosis are regulated by the nuclear factor kappa B (NFkappaB) transcription factor family. This study aimed to address the hypothesis that VEGF-mediated survival effects on endotheliu...

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Publication status:
Published

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Publisher copy:
10.1016/j.bbrc.2005.12.095

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Biochemical and biophysical research communications
Volume:
340
Issue:
3
Pages:
984-994
Publication date:
2006-02-05
DOI:
EISSN:
1090-2104
ISSN:
0006-291X
URN:
uuid:18997a8b-c562-426c-802c-3e94a1784a22
Source identifiers:
224961
Local pid:
pubs:224961

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