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Induction of dominant transplantation tolerance by an altered peptide ligand of the male antigen Dby.

Abstract:

T cell reactivity to minor histocompatibility (mH) antigens is responsible for rejection of HLA-matched allografts, limiting the effectiveness of transplantation for the treatment of end-stage organ failure. The deadbox gene Dby is located on the Y chromosome and encodes an mH antigen that prompts rejection of male tissues by female mice. Establishing a network of regulatory T (T(reg)) cells that is capable of coercing naive cells to adopt a tolerant phenotype offers an attractive strategy fo...

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Publisher copy:
10.1172/jci20569

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Fairchild, PJ More by this author
Journal:
The Journal of clinical investigation
Volume:
113
Issue:
12
Pages:
1754-1762
Publication date:
2004-06-05
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
URN:
uuid:1877d272-7d71-4aeb-8afa-f0f77c5e3271
Source identifiers:
3274
Local pid:
pubs:3274

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