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Large-scale candidate gene study of leprosy susceptibility in the Karonga district of northern Malawi.

Abstract:

We present a large case-control candidate gene study of leprosy susceptibility. Thirty-eight polymorphic sites from 13 genes were investigated for their role in susceptibility to leprosy by comparing 270 cases with 452 controls in Karonga district, northern Malawi. Homozygotes for a silent T-->C change in codon 352 of the vitamin D receptor gene appeared to be at high risk (odds ratio [OR] = 4.3, 95% confidence interval [CI] = 1.6-11.4, P = 0.004), while homozygotes for the McCoy b blood g...

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Publication status:
Published

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Journal:
The American journal of tropical medicine and hygiene
Volume:
71
Issue:
3
Pages:
330-340
Publication date:
2004-09-05
EISSN:
1476-1645
ISSN:
0002-9637
URN:
uuid:187772f2-bda5-4551-b70b-1e9699809ba9
Source identifiers:
32848
Local pid:
pubs:32848

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