Human chorionic gonadotropin-secreting clear cell renal cell carcinoma with paraneoplastic gynaecomastia.

Journal article

A 60-year-man presented with painful gynaecomastia and polycythaemia due to a beta-human chorionic gonadotropin (HCG)-secreting clear cell renal cell carcinoma. A computed tomographic scan of his chest, abdomen and pelvis showed an enhancing 9x9 cm mass in the right kidney suggestive of a renal cell carcinoma. He underwent right radical nephrectomy and the histology showed a clear cell renal cell carcinoma. Following his nephrectomy, over the next 6 months, his gynaecomastia regressed and serum beta-HCG levels became undetectable. Nine months after his nephrectomy, he developed a paratesticular lesion involving scrotal skin, for which he underwent a right radical orchidectomy. Histopathology of the paratesticular lesion showed metastatic renal cell carcinoma.

Authors: Mohammed Ilyas, M; Turner, G; Cranston, D

• Publication status: Published
• Journal: Scandinavian journal of urology and nephrology
• Volume: 42
• Issue: 6
• Pages: 555-557
• Publication date: 2008-01-01
• DOI: 10.1080/00365590802468834
• EISSN: 1651-2065
• ISSN: 0036-5599
• Language: English
• Keywords: Middle Aged; Chorionic Gonadotropin; Follow-Up Studies; Gynecomastia; Tomography, X-Ray Computed; Humans; Tumor Markers, Biological; Diagnosis, Differential; Carcinoma, Renal Cell; Paraneoplastic Syndromes; Kidney Neoplasms; Male