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Deliberate self-harm is associated with allelic variation in the tryptophan hydroxylase gene (TPH A779C), but not with polymorphisms in five other serotonergic genes.

Abstract:

BACKGROUND: There is a heritable component to suicidal behaviour, encouraging the search for the associated risk alleles. Given the putative role of the 5-HT (5-hydroxytryptamine; serotonin) system in suicidal behaviour, serotonergic genes are leading candidates. In particular, several studies have reported an association with variants in the tryptophan hydroxylase (TPH) gene. METHOD: We studied six serotonergic gene polymorphisms in a well-characterized sample of 129 deliberate self-harm sub...

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Publication status:
Published

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Publisher copy:
10.1017/s0033291703007463

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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
Journal:
Psychological medicine
Volume:
33
Issue:
5
Pages:
775-783
Publication date:
2003-07-05
DOI:
EISSN:
1469-8978
ISSN:
0033-2917
URN:
uuid:1869abaa-8fe1-46cc-9dcb-998fe2d22e87
Source identifiers:
98071
Local pid:
pubs:98071

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