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The total synthesis of the annonaceous acetogenin, muricatetrocin C.

Abstract:
The total synthesis of the potential antitumour agent muricatetrocin C has provided an ideal stage for the exploitation and development of new chemistry. A convergent synthetic strategy has been realised incorporating three distinct pieces of methodology, these include a highly diastereoselective hetero-Diels-Alder reaction to construct the butenolide terminus, an oxygen to carbon rearrangement to install the trans-2,5-disubstituted tetrahydrofuran ring and a spatial desymmetrisation process to afford the anti-diol unit.

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Reynolds, DJ More by this author
Journal:
Chemistry (Weinheim an der Bergstrasse, Germany)
Volume:
8
Issue:
7
Publication date:
2002-04-02
ISSN:
0947-6539
URN:
uuid:185a39f7-80f9-4a72-9f4d-10a5dd3ff26a
Source identifiers:
327091
Local pid:
pubs:327091
Language:
English

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