Journal article

Drug targeting of one or more aminoacyl-tRNA synthetase in the malaria parasite Plasmodium falciparum

Abstract:: Malaria remains a major infectious disease and, despite incidence reduction, it threatens resurgence in drug-resistant forms. Antimalarial drugs remain the mainstay of therapeutic options and hence there is a constant need to identify and validate new druggable targets. Plasmodium falciparum aminoacyl-tRNA synthetases (Pf-aaRSs) drive protein translation and are potent targets for development of next-generation antimalarials. Here, we detail advances made in structural-biology-based investigations in Pf-aaRSs and discuss their distribution of druggable pockets. This review establishes a platform for systematic experimental dissection of malarial parasite aaRSs as a new focus for sustained drug development efforts against malaria.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Manickam, Y., Chaturvedi, R., Babbar, P., Malhotra, N., Jain, V., & Sharma, A. (2018). Drug targeting of one or more aminoacyl-tRNA synthetase in the malaria parasite Plasmodium falciparum. Drug Discovery Today, 23(6), 1233–1240.

MLA Style

Manickam, Y., et al. “Drug Targeting of One or More Aminoacyl-TRNA Synthetase in the Malaria Parasite Plasmodium Falciparum.” Drug Discovery Today, vol. 23, no. 6, Elsevier, 2018, pp. 1233–40.

Chicago Style

Manickam, Y, R Chaturvedi, P Babbar, N Malhotra, V Jain, and A Sharma. 2018. “Drug Targeting of One or More Aminoacyl-TRNA Synthetase in the Malaria Parasite Plasmodium Falciparum.” Drug Discovery Today 23 (6): 1233–40.
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Publisher copy:: 10.1016/j.drudis.2018.01.050

Authors

+ Manickam, Y More by this author

Role:: Author

+ Chaturvedi, R More by this author

Role:: Author

+ Babbar, P More by this author

Role:: Author

+ Malhotra, N More by this author

Role:: Author

+ Jain, V More by this author

Institution:: University of Oxford
Division:: MSD
Department:: NDM
Sub department:: Structural Biology
Role:: Author

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Publisher:: Elsevier
Journal:: Drug Discovery Today More from this journal
Volume:: 23
Issue:: 6
Pages:: 1233-1240
Publication date:: 2018-02-08
DOI:: 10.1016/j.drudis.2018.01.050
EISSN:: 1878-5832
ISSN:: 1359-6446
Pmid:: 29408369

Language:: English
Pubs id:: pubs:823474
UUID:: uuid:1853ec10-9669-4ba1-b224-d914ed01f71f
Local pid:: pubs:823474
Source identifiers:: 823474
Deposit date:: 2018-05-31

Terms of use

Copyright holder:: Elsevier Ltd
Copyright date:: 2018

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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