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Foxp3 drives oxidative phosphorylation and protection from lipotoxicity.

Abstract:

Tregs can adopt a catabolic metabolic program with increased capacity for fatty acid oxidation-fueled oxidative phosphorylation (OXPHOS). It is unclear why this form of metabolism is favored in Tregs and, more specifically, whether this program represents an adaptation to the environment and developmental cues or is "hardwired" by Foxp3. Here we show, using metabolic analysis and an unbiased mass spectroscopy-based proteomics approach, that Foxp3 is both necessary and sufficient to program Tr...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1172/jci.insight.89160

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Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Publisher:
American Society for Clinical Investigation Publisher's website
Journal:
JCI Insight Journal website
Volume:
2
Issue:
3
Pages:
e89160
Publication date:
2017-02-05
Acceptance date:
2016-12-30
DOI:
ISSN:
2379-3708
Pubs id:
pubs:680829
URN:
uri:18480325-bee8-46b9-8bbb-d069a1ffaf66
UUID:
uuid:18480325-bee8-46b9-8bbb-d069a1ffaf66
Local pid:
pubs:680829
Language:
English
Keywords:

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